Smart Water Meter Using Electrical Resistance Tomography

Smart flow monitoring is critical for sewer system management. Obstructions and restrictions to flow in discharge pipes are common and costly. We propose the use of electrical resistance tomography modality for the task of smart wastewater metering. This paper presents the electronics hardware design and bespoke signal processing to create an embedded sensor for measuring flow rates and flow properties, such as constituent materials in sewage or grey water discharge pipes of diameters larger than 250 mm. The dedicated analogue signal conditioning module, zero-cross switching scheme, and real-time operating system enable the system to perform low-cost serial measurements while still providing the capability of real-time capturing. The system performance was evaluated via both stationary and dynamic experiments. A data acquisition speed of 14 frames per second (fps) was achieved with an overall signal to noise ratio of at least 59.54 dB. The smallest sample size reported was 0.04% of the domain size in stationary tests, illustrating good resolution. Movements have been successfully captured in dynamic tests, with a clear definition being achieved of objects in each reconstructed image, as well as a fine overall visualization of movement

Characterization of the Active Ingredient and Prediction of the Potential Mechanism of Dahuoluo Pill via Mass Spectrometry with the Network Pharmacology Method

The Dahuoluo pill (DHLP) is a classic Chinese patent medicine used to treat rheumatoid arthritis and other conditions. However, there has been no research on the chemical components of DHLP and the mechanisms by which it ameliorates rheumatoid arthritis. Hence, we analysed the chemical components of DHLP and the DHLP components absorbed in blood by using ultraperformance liquid chromatography-Q-exactive-orbitrap-mass spectrometry. We then used network pharmacology to predict the underlying mechanisms by which DHLP ameliorates rheumatoid arthritis. We identified 153 chemical compounds from DHLP, together with 27 prototype components absorbed in blood. We selected 48 of these compounds as potential active ingredients to explore the mechanism. These compounds are related to 88 significant pathways, which are linked to 18 core targets. This study preliminarily reveals the potential mechanisms by which DHLP ameliorates rheumatoid arthritis and provides a basis for further evaluation of the drug’s efficacy